How it works

The Medtronic Symplicity blood pressure procedure provides another treatment option for people with uncontrolled high blood pressure.1–3


Illustration of a patient receiving blood pressure check with readings of systolic and diastolic blood pressure shown


What the
Symplicity procedure does

The Symplicity blood pressure procedure calms excessively active nerves connected to the kidneys that may be contributing to your high blood pressure.4

Expect a safe and effective procedure.

  • No negative effect on kidney function5,6
  • > 25,000 people worldwide have received it7

Adverse events include, but are not limited to, bruising and pain. Results may vary.

One day to help lower your blood pressure

The Symplicity blood pressure procedure usually only takes up one day of your schedule, and can be done on an outpatient basis with your doctor's approval.


Listen to real patients.

See how the Symplicity blood pressure procedure has helped people reduce their blood pressure.

Testimonials are individual experiences. Their thoughts and opinions are their own. Not every person will experience the same results.



Kandzari DE, Townsend RR, Kario K, et al. Safety and Efficacy of Renal Denervation in Patients taking Antihypertensive Medications. J Am Coll Cardiol. 2023;82(19):1809–1823.


Böhm M, Kario K, Kandzari DE, et al. Efficacy of catheter-based renal denervation in the absence of antihypertensive medications (SPYRAL HTN-OFF MED Pivotal): a multicentre, randomised, sham-controlled trial. Lancet. May 2, 2020;395(10234):1444–1451.


Mahfoud F, et al. Outcomes following radiofrequency renal denervation according to antihypertensive medications: subgroup analysis of Global SYMPLICITY Registry DEFINE. Presented at euroPCR 2023. Includes Syplicity Spyral™ and Flex catheters.


Ettehad D, Emdin CA, Kiran A, et al. Blood pressure lowering for prevention of cardiovascular disease and death: a systematic review and meta-analysis. Lancet. March 5, 2016;387(10022):957–967.


Mahfoud F, Mancia G, Schmieder R, et al. Renal denervation in high-risk patients with hypertension. J Am Coll Cardiol. June 16, 2020;75(23):2879–2888.


Böhm M, Mahfoud F, Williams B, et al. Renal denervation with Symplicity Spyral™ catheter in the Global Symplicity Registry: Safety and efficacy at 3 years. Poster. TCT 2019.


Medtronic data on file. Includes Symplicity Spyral™ and Flex catheters.