We are dedicated to helping you assess treatment efficacy and track disease activity overtime.
With direct visualization, high-definition images, and easy-to-use software, the PillCam™ SB 3 system empowers you with impactful diagnostic and monitoring capabilities.([FOOTNOTE=PillCam™ Capsule Endoscopy RAPID™ v8.3 User Manual.],[ANCHOR=],[LINK=])
We’re proud to partner with the healthcare professionals and organizations that share our goal of advancing Crohn’s disease care.
Download tools to help educate yourself and your community about Crohn's Disease.
Capsule endoscopy has a higher diagnostic yield as compared with SBFT and CTE in detecting early small bowel lesions.([FOOTNOTE=Dionisio PM, Gurudu SR, Leighton JA, Leontiadis GI, Fleischer DE, Hara AK, et al. Capsule endoscopy has a significantly higher diagnostic yield in patients with suspected and established small-bowel Crohn’s disease: a meta-analysis. Am J Gastroenterol. 2010;105(6):1240-8.],[ANCHOR=],[LINK=]),([FOOTNOTE=Leighton JA, Gralnek IM, Cohen SA, Toth E, Cave DR, Wolf DC, et al. Capsule endoscopy is superior to small-bowel follow-through and equivalent to ileocolonoscopy in suspected Crohn’s disease. Clin Gastroenterol Hepatol. 2014;12(4):609-15.],[ANCHOR=],[LINK=]),([FOOTNOTE=Jensen MD, Nathan T, Rafaelsen SR, Kjeldsen J. Diagnostic accuracy of capsule endoscopy for small bowel Crohn’s disease is superior to that of MR enterography or CT enterography. Clin Gastroenterol Hepatol. 2011 Feb;9(2):124-9.],[ANCHOR=],[LINK=])
Mucosal healing is a strong predictor of fewer surgeries, long-term clinical remission, and fewer hospitalizations for Crohn's disease patients.([FOOTNOTE=Reinink AR, Lee TC, Higgins PD. Endoscopic mucosal healing predicts favorable clinical outcomes in inflammatory bowel disease: a meta-analysis. Inflamm Bowel Dis. 2016 Aug;22(8):1859-69.],[ANCHOR=],[LINK=]) Capsule endoscopy can help visualize mucosal healing.
Crohn’s disease can take up to five years to diagnose.([FOOTNOTE=Molodecky NA, Soon IS, Rabi DM, Ghali WA, Ferris M, Chernoff G, et al. Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review. Gastroenterology. 2012 Jan;142(1):46-54.],[ANCHOR=],[LINK=])
75% of patients have lesions in their small bowel.([FOOTNOTE=Engstrom PF, Goosenberg EB. Diagnosis and Management of Bowel Diseases. Caddo, OK. Professional Communications Publisher. 1999.],[ANCHOR=],[LINK=])
Up to 56% of patients have proximal small bowel disease.([FOOTNOTE=Flamant M, Trang C, Maillard O, Sacher-Huvelin S, Le Rhun M, Galmiche JP, et al. The prevalence and outcome of jejunal lesions visualized by small bowel capsule endoscopy in Crohn’s disease. Inflamm Bowel Dis. 2013;19(7):1390-1396.],[ANCHOR=],[LINK=]),([FOOTNOTE=Lazarev M, Huang C, Bitton A, Cho JH, Duerr RH, McGovern DP, et al. Relationship between proximal Crohn’s disease location and disease behavior and surgery: a cross-sectional study of the IBD genetics consortium. Am J Gastroenterol. 2013;108:106-112.],[ANCHOR=],[LINK=])
One study showed 54% of patients with active Crohn’s disease showed negative results on ileoscopy.([FOOTNOTE=Samuel S, Bruining DH, Loftus EV Jr, Becker B, Fletcher JG, Mandrekar JN, et al. Endoscopic skipping of the distal terminal ileum in Crohn’s disease can lead to negative results from ileocolonoscopy. Clin Gastroenterol Hepatol. 2012;10(11):1253-9.],[ANCHOR=],[LINK=])
High incidence of proximal small bowel lesions can lead to poorer prognosis.3,4
$11 billion is roughly the annual burden of illness in the U.S.([FOOTNOTE=Kappelman MD, Rifas-Shiman SL, Porter CQ, Ollendorf DA, Sandler RS, Galanko JA, et al. Direct health care costs of Crohn’s disease and ulcerative colitis in US children and adults. Gastroenterology. 2008;135(6):1907-1913. ],[ANCHOR=],[LINK=]),([FOOTNOTE=Longobardi T, Jacobs P, Bernstein CN. Work losses related to inflammatory bowel disease in the United States: Results from the National Health Interview Survey. Am J Gastroenterol. 2003;98(5):1064-1072.],[ANCHOR=],[LINK=])
Capsule endoscopy has a higher diagnostic yield than SBFT and CTE, in detecting early small bowel lesions.8-10 Capsule endoscopy has shown superiority to MRE for proximal small bowel disease.([FOOTNOTE=Kopylov U, Yung DE, Engel T, et al. Diagnostic yield of capsule endoscopy versus magnetic resonance enterography and small bowel contrast ultrasound in the evaluation of small bowel Crohn’s disease: systematic review and meta-analysis. Digestive and Liver Disease. 2017;49(8):854-86312.],[ANCHOR=],[LINK=])
Unlike SBFT and CTE, capsule endoscopy does not increase cancer risk by exposing the patient to radiation.([FOOTNOTE=Ho IK, Cash BD, Cohen H, Hanauer SB, Inkster M, Johnson DA, et al. Radiation exposure in gastroenterology: improving patient and staff protection. Am J Gastroenterol. 2014;109(8):1180-94.],[ANCHOR=],[LINK=]),([FOOTNOTE=Lauenstein TC, Umutlu L, Kloeters C, Aschoff AJ, Ladd ME, Kinner S. Small bowel imaging with MRI. Acad Radiol. 2012;19(11):1424-33.],[ANCHOR=],[LINK=])
The Lewis Score provides established criteria for making an initial baseline assessment and evaluating disease activity over time.([FOOTNOTE=Cotter J, Castro F, Magalhaes J, Moreira M, Rosa B. Validation of the Lewis score for the evaluation of small-bowel Crohn’s disease activity. Endoscopy. 2015 Apr;47(4):330-5.],[ANCHOR=],[LINK=])
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