Help ensure treatment efficacy with the thorough disease visualization made possible with capsule endoscopy. Studies have shown that 62-85% of Crohn’s disease patients had their medication changed after a capsule endoscopy procedure.8,9
The reliable insights you gain following a capsule procedure support you in making patient management decisions.8-10 80% of Gastroenterologists in a blinded survey said they were extremely confident in changing a prescription based on direct mucosal visualization.([FOOTNOTE=KJT Survey on Crohn’s disease. 2011.],[ANCHOR=],[LINK=])
While capsule retention is sometimes a concern, it has been reported in less than 3% of Crohn’s disease patients.([FOOTNOTE=Liao Z, Gao R, Xu C, Li ZS. Indication and detection, completion, and retention rates of small-bowel capsule endoscopy: a systematic review. Gastrointestinal Endoscopy. 2010;71(2):280-286.],[ANCHOR=],[LINK=]) Prior to capsule endoscopy, you can reduce risk of retention with the PillCam™ patency capsule, a preliminary procedure that suggests passage through the GI tract.
of Crohn’s disease patients require surgical intervention.([FOOTNOTE=Lewis RT, Maron DJ. Efficacy and complications of surgery for Crohn’s disease. Gastroenterol Hepatol. 2010;6(9):587-596.],[ANCHOR=],[LINK=])
Even with surgical intervention, 28-45% of patients have a clinical recurrence at five years and 36-61% at 10 years.([FOOTNOTE=Buisson A, Chevaux JB, Allen PB, Bommelaer G, Peyrin-Biroulet L. Review article: the natural history of postoperative Crohn’s disease recurrence. Alimentary Pharmacology and Therapeutics. 2012;35:625-633.],[ANCHOR=],[LINK=])
Symptoms do not always correlate with disease activity.([FOOTNOTE=Baert F, Moortgat L, Van Assche G, Caenepeel P, Vergauwe P, De Vos M, et al. Mucosal healing predicts sustained clinical remission in patients with early-stage Crohn’s disease. Gastroenterol. 2010 Feb;138(2):463-8.],[ANCHOR=],[LINK=]),([FOOTNOTE=Allez M, Lemann M, Bonnet J, Cattan P, Jian R, Modigliani R. Long term outcome of patients with active Crohn’s disease exhibiting extensive and deep ulcerations at colonoscopy. Am J Gastroenterol. 2002 Apr;97(4):947-53.],[ANCHOR=],[LINK=])
Capsule endoscopy may help to overcome the limitations associated with traditional endoscopic assessment and may be useful in monitoring small bowel mucosal healing during treatment.([FOOTNOTE=Efthymiou A, Viazis N, Mantzaris G, et al. Does clinical response correlate with mucosal healing in patients with Crohn’s disease of the small bowel? A prospective, case-series study using wireless capsule endoscopy. Inflamm Bowel Dis. 2008;14(11):1542-7.],[ANCHOR=],[LINK=])
Direct visualization with capsule endoscopy can impact treatment plans.([FOOTNOTE=Long MD, Barnes E, Isaacs K, Morgan D, Herfarth HH. Impact of capsule endoscopy on management of inflammatory bowel disease: a single tertiary care center experience. Inflamm Bowel Dis. 2011 Sep;17(9):1855-62.],[ANCHOR=],[LINK=]),([FOOTNOTE=Min SB, Le-Carlson M, Singh N, Nylund CM, Gebbia J, Haas K, et al. Video capsule endoscopy impacts decision making in pediatric IBD: A single tertiary care center experience. Inflamm Bowel Dis. 2013 Sept;19(10):2139-45.],[ANCHOR=],[LINK=]),([FOOTNOTE=Cohen SA, Klevens AL. Use of capsule endoscopy in diagnosis and management of pediatric patients, based on meta-analysis. Clin Gastroenterol Hepatol. 2011 Jun;9(6):490-496.],[ANCHOR=],[LINK=])
Make a baseline assessment using established scoring criteria and monitor any changes in the disease over time.([FOOTNOTE=Cotter J, Castro F, Magalhaes J, Moreira M, Rosa B. Validation of the Lewis score for the evaluation of small-bowel Crohn’s disease activity. Endoscopy. 2015 Apr;47(4):330-5.],[ANCHOR=],[LINK=])