CathWorks is now part of Medtronic!
Welcome to CathWorks FFRangio™ system supported by the ALL-RISE trial data.
This milestone represents the culmination of a four-year partnership. We are excited to welcome the CathWorks team and their expertise as we push the boundaries of coronary physiology.
Wire-free, drug-free, multivessel physiology
The CathWorks FFRangio™ system uses a wire-free, drug-free approach to convert routine angiograms into a map of the entire coronary tree, with FFRangio values at every point.
Optimizes clinical decision-making1
The CathWorks FFRangio™ system equips physicians with deep insights to make critical, patient-focused decisions. Built-in tools support planning and optimizing the treatment of coronary artery disease (CAD).†,1
Pullback curve
Plan: the pullback curve differentiates functional patterns of CAD to target critical segments.
Sizing tool
Optimize: the sizing tool accurately measures2 lesion dimensions and co-registers on the angiograms for an alternate view.
The ALL-RISE trial data adds to the robust clinical evidence supporting the CathWorks FFRangio™ system1,3–5 and promotes the use of coronary physiology in assessing and treating CAD.
ALL-RISE sub-analysis of the critical LAD vessel reinforces the results observed with the CathWorks FFRangio system, showing a trend toward lower MACE and statistically significant improvements in resource utilization and procedure time compared to wire-based physiology.1,6,7
59%
ALL-RISE patients had the LAD assessed6
Significant improvements in resource utilization and procedure efficiency in LAD lesions, including:
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The information provided by the CathWorks FFRangio™ system is intended to be used by a qualified clinician in conjunction with the patient’s clinical history, symptoms, and other diagnostic tests, as well as the clinician’s professional evaluation.
† Conditions for use and a full overview of the CathWorks FFRangio™ system can be found in the product user manual.
‡ MACE is a composite rate of all-cause death, myocardial infarction, and unplanned revascularization at one year.
1. Fearon WF, Jeremias A, Witberg G, et al. Angiography-derived fractional flow reserve to guide PCI. N Engl J Med. Published online March 29, 2026. doi:10.1056/NEJMoa2600949.
2. Dan K, Witberg G, Itabashi F, et al. Comparison of angiogram-based physiological assessment system sizing tool and intravascular ultrasound imaging measurements. Cardiovasc Revasc Med. 2025;78:80–85. doi:10.1016/j.carrev.2025.03.012.
3. Fearon WF, Achenbach S, Engstrom T, et al. Accuracy of fractional flow reserve derived from coronary angiography. Circulation. 2019;139(4):477–484. doi:10.1161/CIRCULATIONAHA.118.037350.
4. Witberg G. One-year clinical outcomes of FFRangio-guided treatment of coronary artery disease. Presented at: EuroPCR 2023; May 16–19, 2023; Paris, France.
5. Matsuo H. Prospective randomized trial evaluating clinical outcomes of angiography-based fractional flow reserve guidance versus wire-based fractional flow reserve. Presented at: TCT 2024; October 27–30, 2024; Washington, D.C.
6. McEntegart M. Impact of LAD Lesion Location Upon Outcomes of Coronary Physiology for PCI Decision-Making: Analysis from the ALL-RISE trial Data presented at EuroPCR on May 20, 2026.
7. O’Keefe JH, Kreamer TR et al. Isolated Left Anterior Descending Coronary Artery Disease: Percutaneous Transluminal Coronary Angioplasty Versus Stenting Versus Left Internal Mammary Artery Bypass Grafting. Circulation 1999; 100(2):II-114-II-118
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