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  • Symplicity™ Blood Pressure Procedure
  • Symplicity Spyral™ System
  • Clinical Evidence
  • Reimbursement
  • Patient Selection & Access
  • Symplicity™ RDN Program

    • Selecting the right patients

    Your patient may be indicated for the Symplicity™ procedure, which uses the Symplicity Spyral™ renal denervation (RDN) system, if they:

    Have uncontrolled hypertension

    Consider patients where lifestyle modifications and antihypertensive medications haven’t adequately controlled blood pressure. This may include patients who:

    • Still have high blood pressure despite taking medication
    • Are unable to adhere to or tolerate medication
    • Are on medication for comorbidities that may not be compatible with antihypertensive medication

    Are willing to undergo an interventional procedure

    Consider patients who opt for the Symplicity™ procedure following shared decision-making and an attempt at lifestyle modifications and medical therapy.

    View patient examples (open in new window)

    1 in 3

    patients would consider
    the Symplicity™ procedure
    instead of taking one additional
    antihypertensive medication.1,2
    N = 400

    Examining society recommendations on patient selection for renal denervation

    Society for Cardiovascular Angiography & Interventions (SCAI)3 recommends renal denervation for patients3:

    • With uncontrolled hypertension despite lifestyle changes and medication and are unable or unwilling to take additional medication
    • With resistant hypertension (> 130/80 mmHg) despite being on three medications
    • Who are willing to undergo renal denervation after shared decision-making
    • At higher cardiovascular risk
    Read SCAI statement (open in new window)

    The 2025 hypertension guidelines published by the American College of Cardiology (ACC) and American Heart Association (AHA) recommend renal denervation4:

    • For patients with resistant or uncontrolled blood pressure†,‡ with stage 2 hypertension (office SBP ≥ 140 mmHg and DBP ≥ 90 mmHg)
      • Blood pressure not at goal despite taking ≥ 4 antihypertensive medications at optimal dosages
      • Unable to take antihypertensive medications at the optimal dosages or additional medications
    • Following shared decision-making, considering patient preference to support individualized care decisions

    It is also recommended that institutions follow a team-based approach to care, which is important from patient selection through post-procedure follow-up.

    Review the guidelines (open in new window)

    Patient screening considerations

    When screening patients for the Symplicity™ procedure, consider:

    • Assessing lifestyle modifications
    • Evaluating medications
    • Measuring out of office blood pressure (home or ambulatory)
    • Screening for secondary causes of hypertension (if indicated)

     

    You can also reference our patient screening flowchart as a guide.

    Download flowchart (open in new window)

    Discussing the procedure with your patients

    Once your patient has expressed interest in learning more about the Symplicity™ procedure, we recommend these simple talking points:

    Proven to be safe and effective

    This minimally invasive, safe, and effective procedure complements medication and lifestyle modifications to help lower blood pressure.5–7

    Calms excessively active nerves

    In some people, the nerves connected to the kidneys experience excessive activity that interrupts the natural process of control, leading to higher blood pressure.8 The Symplicity™ procedure calms these nerves that may be contributing to your high blood pressure.9

    Works 24 hours a day

    Once the procedure is done it keeps working 24 hours a day, like a pill you never have to remember to take.5,6

    Adverse events include, but are not limited to, pain and hematoma. Results may vary.

    Download resources that can further support conversations with your patients or share our Symplicity™ procedure patient website with them.

    Download resources

    Helping your patients access the procedure

    When you‘ve identified a patient you think might be a good fit for the procedure and they‘re ready to proceed, we have a few suggestions to get you started:

    Locate a Symplicity™ proceduralist.

    Connect your patients with an experienced proceduralist using our Symplicity™ specialist finder.

    Locate a specialist

    Get a head start with a referral form.

    Complete this form and share with your chosen proceduralist to confirm all necessary patient information is captured and ensure a smooth transition of care for your patient.

    Access referral form (open in new window)

    Understand the benefits of a Symplicity™ RDN program.

    A Symplicity™ program provides a team-based framework, which is needed to develop a successful and sustainable care pathway beyond the procedure itself.

    Review the program

    Connect with us for support.

    Meet with one of our market development specialists to learn more about the procedure, clinical evidence, patient selection, and more. They can also review resources available to support you and your patients.

    Get connected (open in new window)

    Resources to get started

    Patient education materials

    Symplicity™ Blood Pressure Procedure Patient Site

    Patient access resources

    Stay connected.

    Sign up for email so we can send relevant information and resources directly to your inbox.

    Sign up for email (open in new window)

    Browse education and resources.

    Whether you’re new to the Symplicity™ procedure, or you’re ready to help your patients access care, we have resources for you.

    View resources

    Review clinical evidence.

    The Symplicity Spyral™ RDN system is backed by multiple sham-controlled trials and a real-world registry.

    See the data

    Understand coverage.

    Use our coding, coverage, and payment resources to help your patients navigate the reimbursement process.

    Download resources

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