Why sac regression?

  • Sac regression is defined by the Society for Vascular Surgery (SVS) as the reduction in maximum diameter of the aneurysm sac by ≥ 5 mm.6
  • Latest data suggests aneurysm sac regression is associated with better long-term outcomes.7

Addressing sac regression factors with Endurant™ stent graft

Endurant™ AAA stent graft has demonstrated low type I and type II endoleaks in broad patient anatomies,5 with:

  • Accurate placement and controlled deployment2
  • Continuous seal, fixation, and graft conformability3
  • Durable hemostatic barrier and resistance against type II endoleaks4

Endurant™ II-IIs is designed to provide continuous seal in a dynamic environment†,3

Methodology
Radial force was tested and micro-CT scans were evaluated by an independent lab to model the Endurant™ stent graft performance in the proximal seal zone through the cardiac cycle.

Results
M-stent maintains even distribution of contact pressure, resulting in conformability in a pulsatile environment.3

See the Endurant™ II-IIs system perform in a dynamic environment.†

Normalized contact pressure in systole (120 mmHg)†

EVAR success

Aneurysm sac regression is a key indicator6 for EVAR success.

Dr. Ross Milner, MD, Professor of Surgery, Co-director, Center for Aortic Diseases at the University of Chicago, discusses his thoughts on aneurysm sac regression post-EVAR.

A new paradigm shift

Hear physicians’ thoughts on aneurysm sac regression post-EVAR ― watch the on-demand webcast.

  • Moderated by Prof. Jean-Pierre Becquemin, MD
  • Panel includes Prof. Hence Verhagen, MD, PhD; Prof. Michel Reijnen, MD, PhD; and Dr. Apostolos Tassiopoulos, MD

“If you have sac shrinkage in the first year, the need for secondary interventions and therefore the need for intensive follow-up is different than those that don’t shrink.”

–Prof. Hence Verhagen, MD, PhD

Clinical evidence VQI data

Latest data suggests aneurysm sac regression is associated with better long-term outcomes.7

Cohort that demonstrated sac regression at one year had significantly better outcomes than stable and expanding sac cohorts.

Endurant™ stent graft sac regression data associated with better long-term outcomes

ENGAGE OUS Registry confirms sac regression link to better long-term outcomes. Patients with regressing sacs at one year had statistically significant better freedom from (FF) all-cause mortality (ACM) and FF secondary endovascular reinterventions than patients with stable or expanding sacs.8

Freedom from all-cause mortality

Freedom from secondary endovascular reinterventions

The Endurant AAA stent graft is the standard of EVAR durability.9

See the 10-year data

Endurant™ data shows consistent high sac regression rates

Endurant™ demonstrates consistent and high sac regression rates across straightforward and complex anatomies.

10-year sac regression rates‡

1-year sac regression is indicative of 5-year sac dynamics

Of those with sac regression at one year8:

  • 86% of patients with images at five years continue to have sac regression.
  • 2% have sac increase at five years.

Sac dynamics at follow-up time points8

Challenging EVAR procedure video case study

Dr. Ross Milner, MD, reviews the case of a challenging EVAR patient that resulted in a regressing aneurysm sac.

Case study of aneurysm sac regression with the Endurant™ II-IIs AAA stent graft

Related links