Is your patient with dystonia a candidate for DBS therapy?
DBS for dystonia may be appropriate if your patient has chronic primary dystonia, including:
Generalized, segmental†, or cervical dystonia (torticollis) in adult patients
Generalized dystonia in patients 12 years of age or above
Cannot manage symptoms with oral and/or injectable medications or tolerate the side effects
Risks
DBS therapy may help manage some of the symptoms of dystonia, including involuntary movements, but it is not a cure. Potential risks related to the device, therapy, or surgery can include implant site pain, tingling sensations, ineffective stimulation, and implant site infection.
Possible side effects with DBS therapy for dystonia might include:
Status dystonicus
Risk of depression, suicidal ideations, and suicide
Rebound effect: an abrupt cessation of stimulation may cause a return of disease symptoms and in some cases with a greater intensity than prior to implant
Pediatric patients may have increased risk of infections and device-related complications.
Explore Percept™ products.
Discover the Percept™ family of DBS products with BrainSense™ technology.
§ The sensing feature of the Percept™ PC system and Percept™ RC system is intended for use in patients receiving DBS where chronically recorded bioelectric data may provide useful, objective information regarding patient clinical status. Signal may not be present or measurable in all patients treated for dystonia.
1. Medtronic DBS Therapy for Dystonia Clinical Summary, 2025. M944810A003 Rev B
2. Volkmann J. et al. Pallidal neurostimulation in patients with medication-refractory cervical dystonia: a randomised, sham-controlled trial. Lancet Neurol. 2014;13(9):875-884.
3. Kupsch A, Benecke R, Muller J, et al. Pallidal deep-brain stimulation in primary generalized or segmental dystonia. N Engl J Med. 2006;355(19):1978-1990.
4. Krause P, Mahlknecht P, Skogseid IM, et al. Long-term outcomes on pallidal neurostimulation for dystonia: a controlled, prospective 10-year follow-up.
5. Volkmann J. et al. Pallidal deep brain stimulation in patients with primary generalised or segmental dystonia: 5-year follow-up of a randomised trial. Lancet Neurol. 2012;11:1029-38 (suppl mat).