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  1. Healthcare Professionals
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  3. Pain Management
  4. Therapies & Procedures
  5. Targeted Drug Delivery
  6. Conditions
  7. Chronic Pain
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Targeted drug delivery

Chronic pain

Patient selection and clinical evidence

Indications, Safety, and Warnings

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Helping patients manage chronic pain with targeted drug delivery

Targeted drug delivery is effective in reducing or eliminating the need for systemic opioids when used to treat chronic pain.1

SynchroMed™ implantable infusion system

The SynchroMed™ III implantable infusion system delivers prescribed medication directly into the intrathecal space, thereby bypassing the blood-brain barrier. As a result, only a fraction of the oral dose is needed to produce efficacy while minimizing systemic side effects.2

Patient selection: targeted drug delivery for people with chronic intractable pain3

Patient selection for the treatment of chronic intractable pain requires a closer examination of criteria. In most cases, a psychological evaluation is indicated to examine factors such as patient expectations, psychosomatic components of the pain, and secondary gain motivation.

Selection guidelines for patients include:

  • Patient experiences inadequate pain relief and/or intolerable side effects from systemic opioid therapy
  • Patient has objective evidence of pathology
  • Patient obtains psychological clearance
  • Patient has no untreated substance abuse
  • Patient has sufficient body size to accept the bulk and weight of the pump
  • Clear therapy goals and realistic expectations have been established
  • No contraindications to surgery or the therapy exist
  • Patient has a favorable response to the screening test
SynchroMed™ III is an implantable targeted drug infusion system that helps manage chronic pain, cancer pain, and severe spasticity.
Meet SynchroMed™ III
View contraindications

Clinical outcomes

Pain relief

60%

mean pain relief after six months4

Improved quality
of life

87%

of patients who rated their quality of life as fair to excellent5

Patient satisfaction

88%

of patients were satisfied with intrathecal therapy4

Cost-effectiveness

$3,111

Estimated lifetime cost savings per patient/year6

Studies confirm efficacy of targeted drug delivery

Pain relief

  • Significant improvement in back and leg pain at 6 and 12 months (p < 0.001) compared to baseline5
  • 60% mean pain relief after 6 months4

Improved function and quality of life

  • 87% of patients rated their quality of life as fair to excellent5
  • 74% of patients reported increased activity levels4
  • 66% of patients successfully reduced their disability at 12 months5

Patient satisfaction and reduction in oral medication

  • 88% of patients were satisfied with intrathecal therapy4
  • After one year of TDD 43% of patients completely discontinued systemic opioid medication use. Among those continuing systemic medication, the average daily dose decreased in 75% of patients.1
  • 90% of patients would recommend therapy to a family member or friend5
A woman on a green towel at the beach holds a dog.

Cost-effective versus conventional treatments

  • Evidence suggests that the 3 to 5 year costs of TDD may be less compared to conventional medical management (CMM).6,7 Savings were driven by lower inpatient costs and prescription drug costs.6
  • Once study projecting to lifetime cost estimated a savings of $3,111 per patient per year when treated with TDD compared to CMM.6
  • A cost-effectiveness model showed that for the majority of model scenarios TDD was cost-effective relative to conservative medical management over a 10-year time period.8

Discover SychroMed™ III

See how the SynchroMed™ III pump works to help alleviate pain. 

Visit product page

Contact us

Contact a Medtronic representative to learn more about this therapy. 

Contact us

Education and training

Find on-demand resources for targeted drug delivery systems for pain patients.

Visit Medtronic Academy

Contraindications

Contraindications include infection; implant depth greater than 2.5 cm below skin; insufficient body size; spinal anomalies; drugs with preservatives, drug contraindications, drug formulations with pH ≤3, use of catheter access port (CAP) kit for refills or of refill kit for catheter access, blood sampling through CAP in vascular applications, use of the personal therapy manager (PTM) to administer opioid to opioid-naïve patients. See SynchroMed™ product labeling for more information.

 

  1. Hatheway J.A., Bansal M., Nichols-Ricker C.I. 2020. Systemic Opioid Reduction and Discontinuation Following Implantation of Intrathecal Drug-Delivery Systems for Chronic Pain: A Retrospective Cohort Analysis. Neuromodulation. 2020; 23: 961–969
  2.  Hamza M, Doleys D, Wells M, et al. Prospective study of 3-year follow-up of low-dose intrathecal opioids in the management of chronic nonmalignant pain. Pain Med. 2012;13(10): 1304-1313.
  3. Prager, J., et al. (2014), Best Practices for Intrathecal Drug Delivery for Pain. Neuromodulation: Technology at the Neural Interface, 17: 354–372. doi:10.1111/ner.12146.
  4. Roberts LJ, Finch PM, Goucke CR, Price LM. Outcome of intrathecal opioids in chronic noncancer pain. Eur J Pain. 2001;5(4):353–361.
  5. Deer T, Chapple I, Classen A, et al. Intrathecal drug delivery for treatment of chronic low back pain; report from the National Outcomes Registry for Low Back Pain. Pain Med. 2004;5(1):6–13.
  6. Guillemette S, Witzke S, Leier J, Hinnenthal J, Prager JP. Medical cost impact of intrathecal drug delivery for noncancer pain. Pain Medicine. 2013;14:504–515.
  7. Kumar K, Hunter G, Demeria DD. Treatment of chronic pain by using intrathecal drug therapy compared with conventional pain therapies: a cost-effectiveness analysis. J Neurosurg. 2002;97(4):803–810.
  8. Kumar K, Rizvi S, Bishop S. Cost effectiveness of intrathecal drug therapy in management of chronic nonmalignant pain. Clin J Pain. 2013 Feb;29(2):138–45.
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