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  1. Healthcare Professionals
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  3. Pain Management
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  7. Cancer Pain
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Targeted drug delivery

Cancer pain

Patient selection and clinical evidence

Indications, Safety, and Warnings

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Helping patients manage cancer pain with targeted drug delivery

Targeted drug delivery is effective in reducing or eliminating the need for systemic opioids when used to treat cancer-related pain.1

SynchroMed™ implantable infusion system

The SynchroMed™ III implantable infusion system delivers prescribed medication directly into the intrathecal space, thereby bypassing the blood-brain barrier.  As result, only a fraction of the oral dose is needed to sustain pain relief.2

Patient selection and referral guidelines: targeted drug delivery for cancer-related pain

For many cancer patients, oral analgesics may be adequate; however, those cancer patients with intractable pain who meet any of the criteria listed below may be appropriate for more advanced pain management techniques including targeted drug delivery (TDD) using intrathecal opioids. These patients may be candidates for targeted drug delivery (TDD) using intrathecal opioids to control pain.

Pending a successful intrathecal morphine trial, a permanent intrathecal catheter and Medtronic SynchroMed™ III programmable pump may help control your patients’ pain.

See SynchroMed™ III intrathecal pump
SynchroMed™ III is an implantable targeted drug infusion system that helps manage chronic pain, cancer pain, and severe spasticity.

Selection guidelines: targeted drug delivery for cancer patients

Cancer patients with intractable pain who meet any of the criteria below may be candidates targeted drug delivery with SynchroMed™ III

  • Symptoms of pain due to advanced stage cancer at presentation, with a minimum life expectancy of >3 months.3,4,8,9
  • Refractory to conventional pain management because of intractable drug adverse effects or unsatisfactory analgesia.3,4,8,9
  • Visual analog scale (VAS) of ≥ 5, despite 200 mg/day of oral morphine or the analgesic equivalent.†,3,8,9

Consider patients on lower doses if opioid side effects are refractory to conservative treatment and severe enough to prevent upward titration3,8,9

Note: It is important to consider increased assessment and referral vigilance for women,5–7,10 minorities,5–7,11 and the elderly,5,6,11 who have been shown to be at increased risk for inadequate analgesia.

View contraindications
A young medical professional is helping her mature patient as they smiling and laugh together.

Clinical outcomes

Pain relief

Intrathecal drug delivery (IDD) patients more often achieved a reduction in both pain and toxicity compared to patients in the comprehensive medical management (CMM) group.3

Lower side effects

All the measured opioid side effects were reduced more in the IDD group than in the comprehensive medical management (CMM) group.3

Discontinued
opioid use

69% of patients discontinued their systemic opioid pain medications after implantation of the TDD drug infusion system.12

Cost-effectiveness

TDD has been shown to reduce the total all-cause annual payer cost of management of cancer-related pain versus CMM, driven by a reduction in number of inpatient visits and days.13

Refractory cancer pain

Study highlights

This is an image of a female healthcare professional comforting to an older female patient.

Randomized clinical trial of an implantable drug delivery system compared with comprehensive medical management for refractory cancer pain:3

  • Prospective, multicenter, randomized
  • 200 patients with advanced cancer and refractory pain
  • Patients randomly assigned to receive comprehensive medical management (CMM) or intrathecal drug delivery (IDDS) plus CMM, 100 per arm
  • Intrathecal drug delivery was delivered by the SynchroMed™ programmable infusion system
  • Entry criteria included visual analog scale (VAS) pain score of ≥5 on a 0–10 scale despite 200 mg/day of oral morphine or its equivalent, or lower doses with intolerable side effects
  • Demographic and clinical characteristics were well balanced.

Find a pain specialist

Find a referral for a pain management specialist to help manage your cancer patients' pain.

Discover SychroMed™ III

See how the SynchroMed™ III pump works to help alleviate pain. 

Visit product page

Contact us

Contact a Medtronic representative to learn more about this therapy. 

Contact us

Education and training

Find on-demand resources for targeted drug delivery systems for pain patients.

Visit Medtronic Academy

Contraindications

Contraindications may include infection; implant depth greater than 2.5 cm below skin; insufficient body size; spinal anomalies; drugs with preservatives, drug contraindications, drug formulations with pH ≤3, use of catheter access port (CAP) kit for refills or of refill kit for catheter access, blood sampling through CAP in vascular applications, use of the personal therapy manager (PTM) to administer opioid to opioid-naïve patients. See SynchroMed™ product labeling for more information.

† 200 mg oral morphine or equivalent was used as enrollment criterion in a pivotal randomized clinical trial published in 2002,3 and has since been referenced as a criterion in additional clinical studies related to cancer pain and intrathecal drug delivery.8,9


  1. Sindt, J, Odell, D, Dalley, A & Brogan, S. Initiation of Intrathecal Drug Delivery Dramatically Reduces Systemic Opioid Use in Patients With Advanced Cancer. Neuromodulation: Journal of the International Neuromodulation Society. 23, 978–983 (2020).
  2. Perruchoud et al.Management of Cancer Related Pain with Intrathecal Drug Delivery: A Systemic Review and Meta-Analysis of Clinical Studies.  Neudomodulation. 2022; S1094–7159 (21) 06969-5
  3. Smith TJ, Staats PS, Deer T, Stearns LJ, et al. Randomized clinical trial of an implantable drug delivery system compared with comprehensive medical management for refractory cancer pain: impact on pain, drug-related toxicity, and survival. J Clin Oncol. 2002;20(19):4040–4049.
  4. Stearns L, Boortz-Marx R, Du Pen S, Friehs G, et al. Intrathecal drug delivery for the management of cancer pain: a multidisciplinary consensus of best clinical practices. J Support Oncol. 2005;3(6):399–408.
  5. Cleeland CS. Undertreatment of cancer pain in elderly patients. JAMA. 1998;279(23):1914-1915.
  6. Carr D, Goudas L, Lawrence D, et al. Management of cancer symptoms: pain, depression, and fatigue. Evidence Report/Technology Assessment No. 61 (Prepared by the New England Medical Center Evidence-based Practice Center under Contract No 290-97-0019). AHRQ Publication No. 02-E032. Rockville, MD: Agency for Healthcare Research and Quality. July 2002. Accessed at Management of cancer symptoms: pain, depression and fatigue. on 02/15/17.
  7. Cleeland CS, Gonin R, Baez L, Loehrer P, Pandya K. Pain and pain treatment in minority outpatients with metastatic cancer. Ann Intern Med. 1997;127:813–816.
  8. Smith TJ, Coyne PJ. Implantable drug delivery systems (IDDS) after failure of comprehensive medical management (CMM) can palliate symptoms in the most refractory cancer pain patients. J Pall Med. 2005;8(4):736–742.
  9. Brogan, SE. Intrathecal therapy for the management of cancer pain. Curr Pain Head Rep. 2006;10:253–259.
  10. Cleeland CS, Gonin R, Hatfield AK, et al. Pain and its treatment in outpatients with metastatic cancer. N Engl J Med. 1994;330:592–596.
  11. Bernabei R, Gambassi G, Lapane K, Landi F, et al. Management of pain in elderly patients with cancer. JAMA. 1998;279(23):1877–1882.
  12. Brogan SE, Winter NB, Ablodun A, Safapour R. Therapy for refractory cancer pain: identifying factors associated with cost benefit. Pain Med. 2013;14:478–486.
  13. Stearns LJ, Narang S, Albright RE Jr, Hammond K, Xia Y, Richter HB, Paramanandam GK, Haagenson KK, Doth AH. Assessment of Health Care Utilization and Cost of Targeted Drug Delivery and Conventional Medical Management vs Conventional Medical Management Alone for Patients With Cancer-Related Pain. JAMA Netw Open. 2019 Apr 5;2(4):e191549.
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