BONE GRAFT CATEGORISATION Bone Grafting (Spine and Orthopaedic)


Bone graft selection is critical to the outcome of any bone healing procedure. There are currently over 200 different bone grafts available to surgeons today, each with substantial differences in technology, materials, mechanisms of action, indications, and clinical evidence.

Bone grafts can be categorised based on:

  • Composition
  • Mechanism of action (MOA)
  • Approved indication
  • Performance data

Allograft Bone Graft

There are many different allograft products or forms available for use. Some allograft tissue functions through osteoconduction and mild osteoinduction when demineralised, and include mineralised tissue, demineralised tissue, and allograft tissue plus cells.

Grafton™ demineralised bone matrix (DBM) is the most utilised and scientifically studied DBM brand.1 Our aseptic processing technology preserves the function of naturally occurring growth factors — yielding Grafton DBM’s osteoinductivity scores. Proprietary fiber technology offers enhanced osteoconductive scaffold.2

DBM Autograft Extenders Formulated Allografts
  • Composition: Donor bone and tissue
  • Demineralised MOA: osteoconductive and osteoinductive.

Synthetic Bone Graft

An osteoconductor, synthetic autograft extender bulks up the supply of available autograft bone.

Osteoconductive cell carrier and autograft extender
  • Composition: Synthetically produced minerals and ceramics
  • MOA: Provides an osteoconductive passive scaffold for bone formation



Based on Pub-Med search on 8/26/14 with key words Grafton, DBX and Osteosponge.


Martin GJ, Boden SD, Titus L, Scarborough NL New Formulations of Demineralized Bone Matrix as a More Effective Graft Alternative in Experimental Posterolateral Lumbar Spine Arthrodesis. Spine. 1999;24(7):637-645.

See the device manual for detailed information regarding the instructions for use, indications, contraindications, warnings, precautions, and potential adverse events. For further information, contact your local Medtronic representative and/or consult the Medtronic website at