Evolut TAVR Platform
Supra-annular, self-expanding valve design delivers better hemodynamics1 — that go above and beyond.

EOA Matters

A large EOA (effective orifice area) reduces the likelihood of PPM (patient-prosthesis mismatch). Choose Evolut™ TAVR for larger EOAs — allowing patients to maintain a higher exercise capacity.1,2


Supra-annular valves have larger EOAs3

  • A large EOA may improve activity tolerance4 which may allow a faster return to activity.1,2,4

  • A large EOA helps avoid PPM, which correlates to better long-term survival.5

  • A large EOA provides improved flow, less resistance, and better long-term durability.5,6

Evolut TAVR Platform

Top-down view of the supra annular Evolut TAV

Evolut TAVR platform consistent, single-digit gradients

7.1 mm Hg

Evolut PRO Clinical Study at 1 year8

8.3 mm Hg

SURTAVI at 1 year9

8.1 mm Hg

FORWARD at 1 year10

9.1 mm Hg

CoreValve Pivotal High Risk at 1 year11

Gradients Matter

Low gradients

  • Are an indicator of more efficient blood flow12
  • Reduce stress on leaflets12

High gradients

  • Indicate a greater risk of mortality12


Patient-prosthesis mismatch matters


Increase in 1-year mortality in patients with severe PPM13


Increased risk of valve deterioration in patients with moderate/severe PPM6

NYHA Class 3 or 4.



Bleiziffer S, Eichinger WB, Hettich I, et al. Impact of patient-prosthesis mismatch on exercise capacity in patients after bioprosthesis aortic valve replacement. Heart. May 2008;94(5):637-641


van Slooten YJ, van Melle JP, Freling HG, et al. Aortic valve prosthesis-patient mismatch and exercise capacity in adult patients with congenital heart disease. Heart. January 2016;102(2):107-113.


Hahn RT, Leipsic J, Douglas PS, et al. Comprehensive Echocardiographic Assessment of Normal Transcatheter Valve Function. JACC Cardiovasc Imaging. Published online June 8, 2018.


Pibarot P, Dumesnil JG, Jobin J, Cartier P, Honos G, Durand LG. Hemodynamic and physical performance during maximal exercise in patients with an aortic bioprosthetic valve: comparison of stentless versus stented bioprostheses. J Am Coll Cardiol. November 1, 1999;34(5):1609-1617.


Pibarot P, Dumesnil JG. Prosthesis-patient mismatch: definition, clinical impact, and prevention. Heart. August 2006;92(8):1022-1029.


Flameng W, Herregods MC, Vercalsteren M, Herijgers P, Bogaerts K, Meuris B. Prosthesis-patient mismatch predicts structural valve degeneration in bioprosthetic heart valves. Circulation. May 18, 2010;121(19):2123-2129.


Ruel M, Rubens FD, Masters RG, et al. Late incidence and predictors of persistent or recurrent heart failure in patients with aortic prosthetic valves. J Thorac Cardiosvasc Surg. January 2004;127(1):149-159.


Williams MR, Qiao H, Forrest JK, et al. 1-Year Outcomes With The Evolut PRO Self-Expanding Repositionable Transcatheter Aortic Valve With Pericardial Wrap. Presented at ACC Annual Scientific Session and Expo; March 10-12, 2018; Orlando, FL.


Reardon MJ, Van Mieghem NM, Popma JJ, et al. Surgical or Transcatheter Aortic-Valve Replacement in Intermediate-Risk Patients. N Engl J Med. April 6, 2017;376(14):1321-1331.


Grube, et al. 1-year Outcomes Following Real-world Transcatheter Aortic Valve Implantation with a Self-Expanding Repositionable Valve: Results from the FORWARD Study. Presented at EuroPCR 2018; Paris, France.


Adams DH, Popma JJ, Reardon MJ, et al. Transcatheter Aortic-Valve Replacement with a Self-Expanding Prosthesis. N Engl J Med. May 8, 2014;370(19):1790-1798.


Ribeiro HB, Lerakis S, Gilard M, et al. Transcatheter Aortic Valve Replacement in Patients With Low-Flow, Low-Gradient Aortic Stenosis: The TOPAS-TAVI Registry. J Am Coll Cardiol. March 27, 2018 71(12):1297-1308.


Herrmann HC, Daneshvar SA, Fonarow GC, et al. Prosthesis-Patient Mismatch in Patients Undergoing Transcatheter Aortic Valve Replacement: From the STS/ACC TVT Registry. J Am Coll Cardiol. December 4, 2018;72(22):2701-2711.

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