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  • 1. Based on internal white paper #11-PM-0232(1), Cerebral oximetry is frequently a “first alert” indicator of adverse outcomes. April 2016.

  • * The authors received no financial  support for the research,  authorship, and/or publication of this article.

  • 2. Subramanian B, Nyman C, Fritock M, et al. A multicenter pilot study assessing regional cerebral oxygen desaturation frequency during cardiopulmonary bypass and responsiveness to an intervention algorithm. Anesth Analg. 2016;122(6):1786–1793.

  • 3. Anastasiadis K, Antonitsis P, Deliopoulos A, Argiriadou H. A multidisciplinary perioperative strategy for attaining “more physiologic” cardiac surgery. Perfusion. 2017;32(6):446–453