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Peripheral embolization products

Onyx™ liquid embolic system for peripheral embolization

<p>The Onyx™ liquid embolic system is an ethylene vinyl alcohol (EVOH) copolymer dissolved in dimethyl sulfoxide (DMSO) for peripheral embolization.</p>

Ordering information
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Indications

Onyx™ 18 and 34 LES: embolization of lesions in the peripheral and neurovasculature, including arteriovenous malformations, and hypervascular tumors.

Onyx™ 34L  LES: embolization of lesions in the peripheral vasculature, including endoleaks, arteriovenous malformations, portal veins, bleeding, and tumors. 

Product details

Onyx™ is a nonadhesive liquid embolic agent composed of EVOH dissolved in DMSO with suspended micronized tantalum powder. It is delivered through a micro catheter under fluoroscopic control.

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Polymeric properties

  • Precipitation occurs on contact with aqueous solution (e.g., blood, water, contrast)
  • Flows like lava and solidifies from the outside in as solvent diffuses away
  • Delivers in a cohesive manner, forming a spongy, coherent embolus

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Controlled delivery

  • Slow controlled injection and delivery method
  • Ability to start and stop injections (pauses should not exceed two minutes)
  • Cohesive deposition and delivery
  • Excellent visibility3
  • Controlled angiography during embolic injection

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Formulations

Onyx™ 18 and 34 LES for peripheral and neurovascular use:

  • Onyx™ 18 LES (6% EVOH, viscosity of 18 cSt) will travel more distally and penetrate deeper into the targeted lesion due to its lower viscosity compared to Onyx™ 34, (i.e., peripheral AVM nidus)
  • Onyx™ 34 LES (8% EVOH, viscosity of 34 cSt) with higher viscosity for more control in higher flow and large fistulous components

Onyx™ 34L LES for peripheral use:

  • 8% EVOH, viscosity of 34 cSt
  • Lower tantalum content than current version of Onyx™ 34 LES4
  • Less streak artifact on CT with good visibility during injection4

Onyx™ 34L LES packaging with 6 mL vial:

  • 6 mL vial provides ease of use for large volume treatments
  • Requires less storage space than four 1.5 mL vials of Onyx™ 34 LES
  • Environmentally friendly packaging made from 98% recyclable content

CT validation†

Onyx™ 34L LES has less streak artifact on CT with good visibility during injection in comparison to Onyx™ 34 LES.4

This is an image of the Onyx™ 34L liquid embolic system (LES) viewed in a computed tomography (CT) scan.

Onyx™ 34L LES in 10 mm vessel†

 

This is an image of the Onyx™ 34 liquid embolic system (LES) viewed in a computed tomography (CT) scan.

Onyx™ 34 LES in 10 mm vessel†

 

Hemorrhage case

Watch this case overview of a patient with lower gastrointestinal bleeding.

Ordering information

Onyx™ liquid embolic system

Item number Description
105-7200-060 Onyx™ 18 peripheral kit, 1.5 mL
105-7200-080 Onyx™ 34 peripheral kit, 1.5 mL
105-7315-080 Onyx™ 34L kit, 1.5 mL
105-7360-080 Onyx™ 34L kit, 6 mL

Onyx™ liquid embolic system accessories

Item number Description
103-1205-001 Vortex-Genie™* 2 120 v/60 Hz with 1.5 mL vial attachment
103-1205-002 Vortex-Genie™* 2 240 v/50 Hz with 1.5 mL vial attachment
103-1205-100 Mixer attachment for 6 mL and 1.5 mL vials
103-1207 Syringe catheter interface adapter
(20 units/box)
103-1203 1 mL luer lock injector syringe
(10 units/box)  

Resources

Onyx™ publication summaries

Green paper: PeVD embolization Dr Senechal
PeVD embolization Dr Senechal (open in new window)

Summary of the 2021 publication by Dr Sénéchal on the treatment of Pelvic Venous Disorders patients with Onyx.

CLINICAL EVIDENCE PDF 163 KB
PeVD embolization Dr Marcelin
PeVD embolization Dr Marcelin (open in new window)

Summary of the 2017 publication by Dr Marcelin on the treatment of Pelvic Venous Disorders patients with Onyx and coils.

CLINICAL EVIDENCE PDF 136 KB
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Green paper: Bleeding Dr Urbano (open in new window)

Summary of the 2014 publication on selective arterial embolization with ethylene–vinyl alcohol copolymer for control of massive lower gastrointestinal bleeding by Dr Urbano.

CLINICAL EVIDENCE PDF 185 KB
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Bleeding Dr Ayx (open in new window)

Summary of the 2017 publication on treatment of acute hemoptysis by bronchial artery embolization with the liquid embolic agent Ethylene Vinyl Alcohol Copolymer by Dr Ayx.

CLINICAL EVIDENCE PDF 134 KB
Document thumbnail
Bleeding Dr Tipaldi (open in new window)

Summary of the 2018 publication on trans arterial embolization of nonvariceal upper gastrointestinal bleeding by Dr Tipaldi.

CLINICAL EVIDENCE PDF 115 KB
Endoleaks Dr Fanelli Green paper
Endoleaks Dr Fanelli (open in new window)

Summary of the 2020 publication on direct percutaneous embolization of aneurysm sac by Dr Fanelli.

CLINICAL EVIDENCE PDF 194 KB
Endoleaks by Dr Mozes Green paper
Endoleaks by Dr Mozes (open in new window)

Summary of the 2020 publication on outcomes of Onyx embolization of type II endoleaks after endovascular repair of Abdominal Aortic Aneurysms by Dr Mozes.

CLINICAL EVIDENCE PDF 114 KB
Endoleaks by Dr Massis Green paper
Endoleaks by Dr Massis (open in new window)

Green paper by Dr Massis on the treatment of type II endoleaks with ethyline-vinyl-alcohol copolymer (Onyx).

CLINICAL EVIDENCE PDF 127 KB

Related links

TM* Third-party brands are trademarks of their respective owners.

† CT artifact validation in vitro using a water phantom tank to simulate body tissue and synthetic vessel. Document TR_NV 11300 RevA.

‡ Images are property of Medtronic.

  1. Urbano J, Manuel Cabrera J, Franco A, Alonso-Burgos A. Selective arterial embolization with ethylene-vinyl alcohol copolymer for control of massive lower gastrointestinal bleeding: feasibility and initial experience. J Vasc Interv Radiol. 2014;25(6):839–846.
  2. Yamada R, Uflacker A, Bourgeois A, Adams JD, Guimaraes. EVOH/DMSO in Peripheral Application. Embolization Therapy: Principles and Clinical Applications. Philadelphia. Wolters Kluwer Health. 2014. 582.

  1. Pérez-Higueras A, López RR, Tapia DQ. Endovascular treatment of cerebral AVM: Our experience with Onyx. Interv Neuroradiol. 2005;11(Suppl 1):141–57.
  2. Onyx™ LES instructions for use, 70721-001. Rev January 2013.