A Symplicity Spyral™ renal denervation (RDN) system is inside a blue and green kidney.

Therapies and procedures

Symplicity™ blood pressure procedure

Lifestyle changes and medications have defined hypertension care — until now. Learn how the Symplicity™ procedure complements existing treatments to lower blood pressure.

Indications, Safety, and WarningsThe material on this website should not be considered the exclusive source of information, it does not replace or supersede information contained in the device manual(s).Please note that the intended use of a product may vary depending on geographical approvals.See the device manual(s) for detailed information regarding the intended use, the implant procedure, indications, contraindications, warnings, precautions, and potential adverse events.For a MRI compatible device(s), consult the MRI information in the device manual(s) before performing a MRI.If a device is eligible for eIFU usage, instructions for use can be found at Medtronic’s website manuals.medtronic.com.Manuals can be viewed using a current version of any major internet browser. For best results, use Adobe Acrobat® Reader with the browser.Medtronic products placed on European markets bear the CE mark and the UKCA mark (if applicable). For any further information, contact your local Medtronic representative.

This is the turning point in hypertension care.

Current hypertension care strategies are not aIways enough to help patients achieve blood pressure control. The Symplicity™ procedure is an interventional approach using a single catheter and radiofrequency (RF) energy to help lower blood pressure.

80% of hypertension patients do not have their blood pressure under control,¹ yet reducing blood pressure can significantly impact risk for cardiovascular events.

A 10 mmHg reduction in office systolic blood pressure decreases risk for²:

Major CV events by 20%
Stroke by 27%
Heart failure by 28%

Read on to preview:

Evidence showing safety and efficacy
How the system works
Patient selection considerations

Evidence showing safety and efficacy

The Symplicity Spyral™ renal denervation system is proven to achieve significant, safe, and sustained blood pressure reductions in the presence and absence of medications in multiple clinical trials and a real-world patient registry.^3–6

Review evidence

How the system works

The Symplicity Spyral™ system is comprised of the Symplicity Spyral™ multi-electrode renal denervation catheter and the Symplicity G3™ renal denervation RF generator.

Patients whose blood pressure is difficult to control may have an overactive sympathetic nervous system. The Symplicity™ procedure aims to suppress this inappropriately elevated sympathetic drive. The Symplicity Spyral™ system offers a versatile, simple, and minimally invasive method to perform renal denervation.^§,7

The procedure is performed by interventionalists due to its similarity to other procedures they perform every day.

View system details

Patient selection considerations

Understanding which patients could benefit from the Symplicity™ procedure is an important step when considering this therapy.

Learn more about patient selection

Your patients may benefit if they:

Have uncontrolled hypertension

Consider patients where lifestyle modifications and antihypertensive medications haven’t adequately controlled blood pressure.

Are willing to undergo an interventional procedure

Consider patients who opt for the Symplicity™ procedure following shared decision-making and an attempt at lifestyle modifications and medical therapy.

Recommended by cardiovascular experts

The European Society of Cardiology (ESC) 2024 Guidelines, and the European Society oh Hypertension (ESH) 2023 Guidelines both recommend renal denervation as a safe and effective complementary treatment option to control blood pressure. Read the full statements to learn more.

ESC guidelines (open in new window)

ESH guidelines (open in new window)

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Products

† Results may vary across patients.

‡ Includes Symplicity Spyral™ and Flex catheters.

§ One catheter size treats vessels 3–8 mm.

World Health Organization. Hypertension fact sheet. https://www.who.int/news-room/fact-sheets/detail/hypertension. Accessed May 20, 2024.
Ettehad D, Emdin CA, Kiran A, et al. Blood pressure lowering for prevention of cardiovascular disease and death: a systematic review and meta-analysis. Lancet. 2016;387(10022):957-967. doi: 10.1016/S0140-6736(15)01225-8.
Böhm M, Kario K, Kandzari DE, et al. Efficacy of catheter-based renal denervation in the absence of antihypertensive medications (SPYRAL HTN-OFF MED Pivotal): a multicentre, randomised, sham-controlled trial. Lancet. 2020;395(10234):1444–1451. doi: 10.1016/S0140-6736(20)30554-7.
Kandzari D, Townsend R, Kario K, et al. Safety and efficacy of renal denervation in patients taking antihypertensive medication. J Am Coll Cardiol. 2023;82(19):1809–1823. doi: 10.1016/j.jacc.2023.08.045.
Mahfoud F, Kandzari DE, Kario K, et al. Long-term efficacy and safety of renal denervation in the presence of antihypertensive drugs (SPYRAL HTN-ON MED): a randomised, sham-controlled trial. Lancet. 2022;399(10234):1401–1410. doi: 10.1016/S0140-6736(22)00455-X.
Mahfound F, Mancia G, Schmieder R, et al. Outcomes following radiofrequency renal denervation according to antihypertensive medications: subgroup analysis of the Global SYMPLICITY Registry DEFINE. EuroPCR 2023.
Medtronic Symplicity Spyral™ multi-electrode renal denervation catheter instructions for use.