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Symplicity™ blood pressure procedure

Patient selection and access

The Symplicity™ procedure — which uses the Symplicity Spyral™ renal denervation system — provides another treatment option for patients struggling with hypertension. Read on to understand which patients might benefit from this procedure, how to explain it to them, and how to help them access care. Also be sure to sign up for email updates.

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Indications, Safety, and WarningsThe material on this website should not be considered the exclusive source of information, it does not replace or supersede information contained in the device manual(s).Please note that the intended use of a product may vary depending on geographical approvals.See the device manual(s) for detailed information regarding the intended use, the implant procedure, indications, contraindications, warnings, precautions, and potential adverse events.For a MRI compatible device(s), consult the MRI information in the device manual(s) before performing a MRI.If a device is eligible for eIFU usage, instructions for use can be found at Medtronic’s website manuals.medtronic.com.Manuals can be viewed using a current version of any major internet browser. For best results, use Adobe Acrobat® Reader with the browser.Medtronic products placed on European markets bear the CE mark and the UKCA mark (if applicable). For any further information, contact your local Medtronic representative.

Patient selection consideration

When thinking about which of your hypertension patients could benefit from the Symplicity™ procedure, consider those who:

Have uncontrolled hypertension

Consider patients where lifestyle modifications and antihypertensive medications haven’t adequately controlled blood pressure.

Are willing to undergo an interventional procedure

Consider patients who opt for the Symplicity™ procedure following shared decision-making and an attempt at lifestyle modifications and medical therapy.

30% of patients

would be willing to consider an interventional approach to manage hypertension versus an additional medication.^1,2(N = 400)

Download the ESC guidelines summary (open in new window)

Helping your patients access care

If you think you‘ve identified a potential patient for the Symplicity™ procedure, first review the benefits and risks with them. Use the following resources to support discussions with your patients and help them understand the procedure:

Learn more about the Symplicity™ procedure.

Symplicity™ blood pressure procedure referrer brochure

Symplicity™ blood pressure procedure referrer brochure (open in new window)

CLINICAL EVIDENCE PDF 3 MB

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Related pages

Related products

Kandzari DE, Weber MA, Poulos C, et al. Patient preferences for pharmaceutical and device-based treatments for uncontrolled hypertension: discrete choice experiment. Circ Cardiovasc Qual Outcomes. 2023;16(1):e008997. doi: 10.1161/CIRCOUTCOMES.122.008997.
Symplicity Spyral™ renal denervation system. Sponsor presentation. U.S. FDA Circulatory Systems Devices Panel. Meeting date August 23, 2023.
Kandzari D, Townsend R, Kario K, et al. Safety and efficacy of renal denervation in patients taking antihypertensive medication. J Am Coll Cardiol. 2023;82(19):1809–1823. doi: 10.1016/j.jacc.2023.08.045.
FDA Executive Summary Prepared for the August 23, 2023 Meeting of the Circulatory System Devices Panel. Accessed May 20, 2024.

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