You just clicked a link to go to another website. If you continue, you may go to a site run by someone else.
It is possible that some of the products on the other site are not approved in your region or country.
Your browser is out of date
With an updated browser, you will have a better Medtronic website experience. Update my browser now.
The content of this website is exclusively reserved for Healthcare Professionals in countries with applicable health authority product registrations.
Click “OK” to confirm you are a Healthcare Professional.
For treating hypertension
The Symplicity Spyral™ renal denervation system complements medication and lifestyle changes with an effective, evidence-based procedural approach to hypertension treatment.¹⁻⁴
The Symplicity Spyral renal denervation system:
In the SPYRAL HTN-ON MED pilot study, at three years, blood pressure reductions with the Symplicity blood pressure procedure were present throughout the day and night, including the high-risk zone in the late night and early morning period, which is usually associated with increased risk for stroke and cardiovascular events.3
Symplicity Spyral Renal Denervation Procedure - (03:22)
Seen how the Symplicity Spyral renal denervation procedure works to help treat hypertension.
More information (see more) Less information (see less)
Watch a short animation that explains the mechanism of action for RF renal denervation with the Symplicity Spyral system.
In typical uncontrolled hypertension patients.
ANCOVA adjusted; secondary efficacy analysis.
RDN arm reduction from baseline.
Includes Symplicity Spyral™ and Flex™ catheters.
Böhm M, Kario K, Kandzari DE, et al. Efficacy of catheter-based renal denervation in the absence of antihypertensive medications (SPYRAL HTN-OFF MED Pivotal): a multicentre, randomised, sham-controlled trial. The Lancet. 2020;395:1444–1451.
Kandzari DE, Böhm M, Mahfoud F, et al. Effect of renal denervation on blood pressure in the presence of antihypertensive drugs: 6-month efficacy and safety results from the SPYRAL HTN-ON MED proof-of-concept randomised trial. The Lancet. 2018;391(10137):2346–2355.
Mahfoud F, Mancia G, Schmieder R, et al. Three-year safety and efficacy in the Global Symplicity Registry: Impact of antihypertensive medication burden on blood pressure reduction. Presented at PCR e-course 2020.
Mahfoud F, Kandzari DE, Kario K, et al. Long-term efficacy and safety of renal denervation in the presence of antihypertensive drugs (SPYRAL HTN-ON MED): a randomised, sham-controlled trial. The Lancet. 2022;399:1401–1410.
Coates P, Tunev S, Trudel J, et al. Time, temperature, power, and impedance considerations for radiofrequency catheter renal denervation. Cardiovascular Revascularization Medicine. 2022.
Medtronic Data on File.
Medtronic Symplicity Spyral™ Instructions for Use.