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Symplicity™ Blood Pressure Procedure

Lifestyle changes and medications have defined hypertension care — until now. Learn how the Symplicity™ procedure complements existing treatments to lower blood pressure.

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Alert Indications, Safety, and Warnings

Transforming hypertension treatment

Current hypertension care strategies are not aIways enough to help patients achieve blood pressure control. The Symplicity™ procedure is an interventional approach using a single catheter and radiofrequency (RF) energy to help lower blood pressure. 

80% of hypertension patients do not have their blood pressure under control,1 yet reducing blood pressure can significantly impact risk for cardiovascular events.

A 10 mmHg reduction in office systolic blood pressure decreases risk for2:

  • Major CV events by 20%
  • Stroke by 27%
  • Heart failure by 28%

Read on to preview:

Evidence showing safety and efficacy

The Symplicity Spyral™ renal denervation system is proven to achieve significant, safe, and sustained blood pressure reductions in the presence and absence of medications in multiple clinical trials and a real-world patient registry.3–6

Read evidence

How the Symplicity Spyral™ system works

The Symplicity Spyral™ system is comprised of the Symplicity Spyral™ multi-electrode renal denervation catheter and the Symplicity G3™ renal denervation RF generator.

Patients whose blood pressure is difficult to control may have an overactive sympathetic nervous system. The Symplicity™ procedure aims to suppress this inappropriately elevated sympathetic drive. The Symplicity Spyral™ system offers a versatile, simple, and minimally invasive method to perform renal denervation.§,7

The procedure is performed by interventionalists due to its similarity to other procedures they perform every day.

See the Symplicity Spyral system

 

 

 

Patient selection considerations

Understanding which patients could benefit from the Symplicity™ procedure is an important step when considering this therapy. 

Learn about patient selection

Your patients may benefit if they:

 

Decorative element.
Have
uncontrolled hypertension

Consider patients where lifestyle modifications and antihypertensive medications haven’t adequately controlled blood pressure.

Decorative element.
Are willing to undergo an interventional procedure

Consider patients who opt for the Symplicity™ procedure following shared decision-making and an attempt at lifestyle modifications and medical therapy.

ESC guidelines
ACC-AHA guidelines

Learn from the experts on YouTube

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Related pages

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a) Statement “Registered under Act 737”
b) Medical device registration number: GC3639922-85853
† Results may vary across patients.
‡ Includes Symplicity Spyral™ and Flex catheters.
§ One catheter size treats vessels 3–8 mm.

1

World Health Organization. Hypertension fact sheet. https://www.who.int/news-room/fact-sheets/detail/hypertension. Accessed May 20, 2024.

2

Ettehad D, Emdin CA, Kiran A, et al. Blood pressure lowering for prevention of cardiovascular disease and death: a systematic review and meta-analysis. Lancet. 2016;387(10022):957-967. doi: 10.1016/S0140-6736(15)01225-8.

3

Böhm M, Kario K, Kandzari DE, et al. Efficacy of catheter-based renal denervation in the absence of antihypertensive medications (SPYRAL HTN-OFF MED Pivotal): a multicentre, randomised, sham-controlled trial. Lancet. 2020;395(10234):1444–1451. doi: 10.1016/S0140-6736(20)30554-7.

4

Kandzari D, Townsend R, Kario K, et al. Safety and efficacy of renal denervation in patients taking antihypertensive medication. J Am Coll Cardiol. 2023;82(19):1809–1823. doi: 10.1016/j.jacc.2023.08.045.

5

Mahfoud F, Kandzari DE, Kario K, et al. Long-term efficacy and safety of renal denervation in the presence of antihypertensive drugs (SPYRAL HTN-ON MED): a randomised, sham-controlled trial. Lancet. 2022;399(10234):1401–1410. doi: 10.1016/S0140-6736(22)00455-X.

6

Mahfound F, Mancia G, Schmieder R, et al. Outcomes following radiofrequency renal denervation according to antihypertensive medications: subgroup analysis of the Global SYMPLICITY Registry DEFINE. EuroPCR 2023.

7

Medtronic Symplicity Spyral™ multi-electrode renal denervation catheter instructions for use.