DANISH II

A RANDOMIZED COMPARISON OF ATRIAL AND DUAL-CHAMBER PACING IN 177 CONSECUTIVE PATIENTS WITH SICK SINUS SYNDROME: ECHOCARDIOGRAPHIC AND CLINICAL OUTCOME.

Nielsen JC, Kristensen L, Andersen HR, Mortensen PT, Pedersen OL, Pedersen AK.
JACC. 2003;42(4):614-623

Design: 177 consecutive patients with sick sinus syndrome (SSS) randomized to pacing treatment in AAIR or DDDR with a short AV delay (DDDR-S) or DDDR with a fixed long AV delay (DDDR-I).

Objectives: Compare AAI and DDD pacing in patients with SSS, as measured by echocardiography.

Key Results: Mean Follow-up – 2.9 ± 1.1 years:

• In both DDDR groups, LA diameter increased significantly (P < 0.05)
• In the DDDR-S group, LV fractional shortening decreased significantly (p < 0.01)
• Atrial fibrillation (AF) was significantly less common in the AAIR group (7.4% vs. 17.5% in DDDR-I group and 23.3% in DDDR-S group, p = 0.03, log rank test)
• In the AAIR group, no significant changes were observed in LA or LV diameters

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