Clinical Evidence

Diagnostic accuracy of capsule endoscopy for small bowel Crohn’s Disease is superior to that of MR enterography or CT enterography

Authors: Jensen, M.. et al.
Published in: Clinical Gastroenterology and Hepatology. (2011) 9:124-129.

Conclusion: Patients with newly diagnoses or suspected Crohn’s disease, MRA and CTE are comparable when comparing sensitivities and specificities. For patients who do not have clinical or endoscopic suspicion of stenosis, CE should be the first line procedure for small bowel assessment and detection of Crohn’s disease – beyond the reach of colonoscopy.

ACG clinical guideline: diagnosis and management of small bowel bleeding

Authors: Gerson, L. B. et al.
Published in: ACG Clinical Guideline: Diagnosis and Management of Small Bowel Bleeding. The American Journal of Gastroenterology, 110(9), 1265–1287 (2015). https://doi.org/10.1038/ajg.2015.246

Background and aims: The ACG guideline for small bowel bleeding aims to provide clinical definition of small bowel bleeding, review the diagnostic modalities (including video capsule endoscopy (VCE), endoscopic evaluation, and radiographic modalities), and provide treatment options including endoscopic, medical and surgical options. 

Economic analysis of the adoption of capsule endoscopy within the British NHS

Authors: Lobo, A., Torrejon Torres, R., McAlindon, M., et al.
Published in: International Journal for Quality in Health Care. 2020.

Conclusions: PVCE is likely to be a cost-effective alternative to colonoscopy with or without MRE for CD surveillance. In this model, switching to PVCE resulted in lower treatment costs and gave patients better quality of life.

Panenteric capsule endoscopy versus ileocolonoscopy plus magnetic resonance enterography in Crohn’s disease: a multicentre, prospective study

Authors: Bruining, D., Oliva, S., Fleisher, M., et al.
Published in: BMJ Open Gastroenterology. 2020.

Conclusions: Panenteric CE is able to provide accurate Crohn’s disease assessments compared to dual or more invasive modalities. Panenteric CE should be considered for use in evaluating inflammation in subjects with non-stricturing Crohn’s disease.

Detection of colonic polyps and early colorectal cancer

This document provides a comprehensive overview on the body of evidence that supports the use of Medtronic’s PillCam™ COLON 2 capsule endoscopy system for colorectal cancer screening.