Clinical evidence

Colon capsule endoscopy in colorectal cancer screening: a systematic review

Authors: Fanny E. R. Vuik et al.

Conclusion: CCE appeared to be a safe and effective tool for the detection of CRC and polyps in a screening setting. Accuracy was comparable to colonoscopy and superior to CTC, making CCE a good alternative to colonoscopy in CRC screening programs, although completion rates require improvement.

Does capsule endoscopy impact clinical management in established Crohn’s disease?

Authors: Alfonso Elosua, et al.
Published in: Digestive Endoscopy

Conclusion: SBCE is a useful tool for guiding therapeutic management in CD patients both for treatment escalation and de-escalation.

Panenteric capsule endoscopy identifies proximal small bowel disease guiding upstaging and treatment intensification in Crohn’s disease: A European multicentre observational cohort study

Authors: Foong Way D. Tai et al.
Published in: UEG Journal

Conclusion: Panenteric capsule endoscopy was feasible in routine practice and the ability to detect proximal small bowel disease may allow better estimation of prognosis and guide treatment intensification. Panenteric capsule endoscopy may be a suitable non-invasive endoscopic investigation in determining disease activity and supporting management decisions.

Simplify to improve capsule endoscopy – TOP 100 is a swift and reliable evaluation tool for the small bowel inflammatory activity in Crohn’s disease

Authors: Marta Freitas, Cátia Arieira, Pedro Boal Carvalho, Bruno Rosa, Maria João Moreira & José Cotter
Published in: Scandinavian Journal of Gastroenterology PMID: 1745880

Conclusion: While classical review of the entire CE video remains the gold standard, the TOP 100 is a useful tool in assisting the reader in prompt calculation of LS, particularly for identifying patients with moderate-to-severe inflammatory disease.

Capsule endoscopy: Is the software TOP 100 a reliable tool in suspected small bowel bleeding?

Authors: Arieira, C., Monteiro, S., Dias de Castro, F., et al.
Published in: Digestive and Liver Disease. 2019 Dec; 51(12): 1661-1664

Conclusion: The TOP 100 is an immediate and automated software feature that allows instantaneous identification of the 100 most important images.

Timing of video capsule endoscopy relative to overt obscure GI bleeding: implications from a retrospective study

Authors: Singh, A. et al.
Published in: Gastrointestinal Endoscopy (2013).

Conclusion: Early deployment of VCE within 3 days of admission results in a higher diagnostic yield and therapeutic intervention rate and an associated reduction of length of stay.

Diagnostic accuracy of capsule endoscopy for small bowel Crohn’s Disease is superior to that of MR enterography or CT enterography

Authors: Jensen, M.. et al.
Published in: Clinical Gastroenterology and Hepatology. (2011) 9:124-129.

Conclusion: Patients with newly diagnoses or suspected Crohn’s disease, MRA and CTE are comparable when comparing sensitivities and specificities. For patients who do not have clinical or endoscopic suspicion of stenosis, CE should be the first line procedure for small bowel assessment and detection of Crohn’s disease – beyond the reach of colonoscopy.

ACG clinical guideline: diagnosis and management of small bowel bleeding

Authors: Gerson, L. B. et al.
Published in: ACG Clinical Guideline: Diagnosis and Management of Small Bowel Bleeding. The American Journal of Gastroenterology, 110(9), 1265–1287 (2015). https://doi.org/10.1038/ajg.2015.246

Background and aims: The ACG guideline for small bowel bleeding aims to provide clinical definition of small bowel bleeding, review the diagnostic modalities (including video capsule endoscopy (VCE), endoscopic evaluation, and radiographic modalities), and provide treatment options including endoscopic, medical and surgical options. 

Economic analysis of the adoption of capsule endoscopy within the British NHS

Authors: Lobo, A., Torrejon Torres, R., McAlindon, M., et al.
Published in: International Journal for Quality in Health Care. 2020.

Conclusions: PVCE is likely to be a cost-effective alternative to colonoscopy with or without MRE for CD surveillance. In this model, switching to PVCE resulted in lower treatment costs and gave patients better quality of life.

Panenteric capsule endoscopy versus ileocolonoscopy plus magnetic resonance enterography in Crohn’s disease: a multicentre, prospective study

Authors: Bruining, D., Oliva, S., Fleisher, M., et al.
Published in: BMJ Open Gastroenterology. 2020.

Conclusions: Panenteric CE is able to provide accurate Crohn’s disease assessments compared to dual or more invasive modalities. Panenteric CE should be considered for use in evaluating inflammation in subjects with non-stricturing Crohn’s disease.

Detection of colonic polyps and early colorectal cancer

This document provides a comprehensive overview on the body of evidence that supports the use of Medtronic’s PillCam™ COLON 2 capsule endoscopy system for colorectal cancer screening.