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Unique Features

Implantable Cardiac Devices

Ensure CRT Suite

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Clinical Need

Clinical Need

Studies have shown that up to one-third of patients do not experience all of the benefits of cardiac resynchronization therapy (CRT).1-6

Multiple conditions can hamper CRT response:

  • Suboptimal AV/VV timings -- occurs in 45% of CRT non-responders7
  • Atrial fibrillation (AF) -- the single, largest cause of CRT non-response8
  • Threshold elevation -- may lead to loss of CRT and requires in-office follow-up visits to manage LV capture concerns9

Percentage of Patients with Adequate CRT Response1-6

Adequate CRT Response

Detail - Adequate CRT Response

Potential Factors Contributing to Suboptimal CRT Response7

Suboptimal CRT Response

Detail - Suboptimal CRT Response

Important Safety Information

For CRT-D devices, certain programming and device operations may not provide cardiac resynchronization. Changes in a patient's disease and/or medications may alter the efficacy of a device's programmed parameters.

References

1

Abraham WT, Fisher WG, Smith AL, et al. Cardiac resynchronization in chronic heart failure. NEJM. 2002;346(24):1845-1853.

2

Abraham WT, Young JB, León AR, et al. Effects of cardiac resynchronization on disease progression in patients with left ventricular systolic dysfunction, an indication for an implantable cardioverter-defibrillator, and mildly symptomatic chronic heart failure. Circulation. 2004;110(18):2864-2868.

3

Abraham WT, Leon AR, Hannon C, et al. Results of the InSync III Marquis clinical trial. Heart Rhythm. 2005;2(5): S65.

4

Abraham WT, Gras D, Yu CM, et al. Results from the FREEDOM Trial - assess the safety and efficacy of frequent optimization of cardiac resynchronization therapy. Presented at the Heart Rhythm Society annual scientific session, Denver, CO, May 2010.

5

Young JB, Abraham WT, Smith AL, et al. Combined cardiac resynchronization and implantable cardioversion defibrillation in advanced chronic heart failure; the MIRACLE ICD Trial. JAMA. 2003;289(20):2685-2694.

6

Chung ES, Leon AR, Tavazzi L, et al. Results of the Predictors of Response to CRT (PROSPECT) Trial. Circulation. 2008;117(20):2608-2616.

7

Mullens W, Grimm RA, Verga T, et al. Insights from a cardiac resynchronization optimization clinic as part of a heart failure disease management program. JACC. 2009; 53(9):765-773.

8

Knight BP, Desai A, Coman J, et al. Long-term retention of cardiac resynchronization therapy. J Am Coll Cardiol. July 7, 2004;44(1):72-77.

9

Crossley GH, Mead H, Kleckner K, et al. Automated left ventricular capture management. Pacing Clin Electrophysiol. October 2007; 30(10):1190-1200.

How It Works

CardioSync

AF and CRT

Capture Management